HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 535390Generated: October 31, 2026
Sodium Methoxide → 4-Methoxy-6-(2-phenylethynyl)-5-pyrimidin-5-ylpyridin-2-amine
https://huagongshe.com/reaction/535390
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4-Chloro-6-(2-phenylethynyl)-5-pyrimidin-5-ylpyridin-2-amine | HCID 86694374 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Methoxy-6-(2-phenylethynyl)-5-pyrimidin-5-ylpyridin-2-amine | HCID 86694375 | — |
Reaction Steps
A mixture of 4-chloro-6-(2-phenylethynyl)-5-pyrimidin-5-ylpyridin-2-amine C3c (400 mg, 1.3 mmol), sodium methoxide (a solution of 2.61 mmol in 0.29 ml MeOH) and MeOH (2 ml) is stirred for 20 minutes at 100° C. and 10 minutes at 110° C. The mixture is diluted with water and extracted with DCM. The combined organic layers are dried over Na2SO4, concentrated in vacuo and the product purified by NP chromatography. Yield: 228 mg (58%). HPLC-MS: M+H=303.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08859541B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-bcfa975a25bb4444b244572464c091b6 |
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| Source note | uspto-grants-2014_10 |
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