Dimethylamine → 2-Chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine

Participants

Reaction Steps

Dimethylamine (8 mL) was added to a solution of 3-cyano-2,6-dichloro-4-methylpyridine (11.6 g) in dioxan (100 mL). After stirring for 2 hours the reaction mixture was diluted with ethyl acetate (1 L), washed with water, dried, filtered, and evaporated to a volume of 20 mL. The crystalline material was filtered to give 5.4 g of the title compound, suitable for use in the next reaction.

Provenance & Evidence