HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 6-[(1-Methoxy-2-methylindolizin-3-yl)carbonyl]-2-methyl-4H-3,1-benzoxazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Amino-5-[(1-Methoxy-2-Methylindolizin-3-Yl)carbonyl]benzoic Acid | HCID 11347895 | — |
| Product | 6-[(1-Methoxy-2-methylindolizin-3-yl)carbonyl]-2-methyl-4H-3,1-benzoxazin-4-one | HCID 66653052 | — |
Reaction Steps
0.100 g (0.31 mmol) of 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)-carbonyl]benzoic acid (Example 150 described in WO 03/084956) in 1 ml of acetic anhydride is refluxed for 3 hours. The reaction medium is concentrated under reduced pressure. 0.107 g of a yellow solid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859544B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-41fdf41fe5254cb88462d56bc89beccf |
| Source note | uspto-grants-2014_10 |