HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 535484Generated: October 29, 2026
Sodium Carbonate → 4-(3,6-dihydro-2H-pyran-4-yl)phthalazin-1(2H)-one
https://huagongshe.com/reaction/535484
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-chlorophthalazin-1(2H)-one | HCID 2775142 | — |
| Reactant | 3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester | HCID 11218053 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(3,6-dihydro-2H-pyran-4-yl)phthalazin-1(2H)-one | HCID 70976213 | — |
Reaction Steps
A mixture of 4-chlorophthalazin-1(2H)-one (150 mg, 0.831 mmol), 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (174 mg, 0.831 mmol), Na2CO3 (164 mg, 2.49 mmol) and Pd(PPh3)4 (47.8 mg, 0.042 mmol) in DMF (3 mL) and H2O (1 mL) was heated at 180° C. under microwave condition for 20 minutes. The mixture was diluted with EtOAc and washed with saturated aqueous NaHCO3, dried (Na2SO4), filtered, and concentrated to afford the title compound: MS (APCI) M/Z 229 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08859549B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-266f0e53f35d44598d87afd0e3c18f7b |
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| Source note | uspto-grants-2014_10 |
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