HCID 71469053, compound → HCID 70975810, compound

Participants

Reaction Steps

A mixture of the product of Example 5 (38 mg, 0.089 mmol) and a catalytic amount of 10% Pd/C in MeOH (1 mL) and DMF (0.5 mL) was stirred at room temperature under H2 (1 atm) for 3 hours, filtered through celite, and chromatographed (30-60% EtOAc/DCM) to give 17.8 mg of the title compound as a white solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 11.75 (s, 1H), 8.78 (dd, J=2.2, 0.7 Hz, 1H), 8.76 (dd, J=4.8, 1.6 Hz, 1H), 8.40-8.43 (m, 1H), 8.06 (ddd, J=7.9, 2.2, 1.7 Hz, 1H), 7.94-8.02 (m, 2H), 7.67-7.75 (m, 1H), 7.61 (ddd, J=7.9, 4.8, 0.8 Hz, 1H), 7.40 (s, 4H), 3.71 (s, 2H); MS (ESI+) M/Z 391 (M+H)+.

Provenance & Evidence