Triethylamine → HCID 123642442, compound

Participants

Reaction Steps

A mixture of 4-(aminomethyl)phthalazin-1(2H)-one hydrochloride hydrate (0.300 g, 1.31 mmol), BOC2O (0.314 g, 1.44 mmol), and triethylamine (0.46 mL, 3.3 mmol) in DCM (4.5 mL) was stirred for 2 hours, diluted with EtOAc, washed with saturated NaHCO3 and brine, dried (Na2SO4), filtered, and chromatographed (70% EtOAc/hexanes) to give 313 mg of the title compound as a white solid: 1H NMR (300 MHz, DMSO-d6) δ 12.62-12.50 (m, 1H), 8.30-8.22 (m, 1H), 8.01 (s, 1H), 7.92 (dd, J=11.0, 4.1, 1H), 7.89-7.80 (m, 1H), 7.41-7.26 (m, 1H), 4.44 (d, J=5.8, 2H), 1.39 (s, 9H).

Provenance & Evidence