HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-(3Acetoxypyrrolidin-1-yl)-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 11-Ethyl-2-(3-hydroxypyrrolidin-1-yl)-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one | HCID 463549 | — |
| Product | 2-(3Acetoxypyrrolidin-1-yl)-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 19960044 | — |
Reaction Steps
The title compound, m.p. 188°-189.5° C., was synthesized from 5,11-dihydro-11-ethyl-2-(3- hydroxypyrrolidin-1-yl)-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and acetic anhydride using procedures analogous to those described above. The product was chromatographed over silica gel with ethyl acetate/hexane, and was then crystallized from diisopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620974 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-714d3c071a134c8c86a36f750db1d7fb |
| Source note | uspto-grants-1997_04 |