4-Chlorophenylacetyl chloride → HCID 70976272, compound

HRID 535512Notes

Reaction equation

HRID 535512 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:3]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](Cl)=[O:27])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([NH:1][N:2]2[C:11](=[O:12])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:3]2)=[O:27])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70976064HCID 70976064, compound

Product 1

HCID 70976272HCID 70976272, compound

Procedure

The product from Example 51B and 2-(4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.83 (s, 1H), 8.49 (d, J=8.0, 1H), 8.35 (d, J=7.9, 1H), 8.10-8.01 (m, 1H), 7.97 (dd, J=11.8, 4.3, 1H), 7.47-7.35 (m, 4H), 4.42 (q, J=7.1, 2H), 3.73 (s, 2H), 1.35 (t, J=7.1, 3H); MS (ESI−) M/Z 384 (M−H)−.

Sources & evidence

ORD record
ord-b85bbde8240d41bbb7fbda2fe29b55c8
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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