2-(Oxolan-3-yl)acetic acid → N-[4-(2-chloropyridin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(tetrahydrofuran-3-yl)acetamide

Participants

Reaction Steps

The product from Example 29B and 2-(tetrahydrofuran-3-yl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, CDCl3) δ ppm 8.60-8.60 (bs, 1H), 8.55-8.59 (m, 1H), 8.54-8.57 (m, 1H), 7.84-7.93 (m, 2H), 7.69-7.73 (m, 1H), 7.62 (s, 1H), 7.50-7.53 (m, 1H), 3.92-4.04 (m, 2H), 3.78-3.85 (m, 1H), 3.64-3.68 (m, 1H), 2.77-2.87 (m, 1H), 2.50-2.67 (m, 2H), 2.21-2.30 (m, 1H), 1.69-1.81 (m, 1H); MS (APCI+) M/Z 385 (M+H)+.

Provenance & Evidence