2-(1-Hydroxycyclohexyl)acetic acid → N-[4-(2-chloropyridin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(1-hydroxycyclohexyl)acetamide

Participants

Reaction Steps

The product from Example 29B and 2-(1-hydroxycyclohexyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (500 MHz, CDCl3) δ ppm 9.29 (s, 1H), 8.58 (d, J=4.9 Hz, 1H), 8.52-8.57 (m, 1H), 7.82-7.93 (m, 2H), 7.70-7.72 (m, 1H), 7.62 (s, 1H), 7.50 (dd, J=5.0, 1.4 Hz, 1H), 2.62 (s, 2H), 1.79-1.90 (m, 3H), 1.65-1.74 (m, 2H), 1.52-1.65 (m, 5H), 1.28-1.38 (m, 1H)); MS (APCI+) M/Z 413 (M+H)+.

Provenance & Evidence