HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-Chloro-3-cyano-6-(imidazol-1-yl)-4-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 3-Cyano-2,6-dichloro-4-methylpyridine | HCID 70131 | — |
| Reactant | Chloroform ethanol | HCID 21889567 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Chloro-3-cyano-6-(imidazol-1-yl)-4-methylpyridine | HCID 19960034 | 22.9% |
Reaction Steps
A solution of 2,6-dichloro-3-cyano-4-methylpyridine (5.6 g) and imidazole (2.04 g) in dimethylformamide (10 mL) was heated at 130° C. for 1.25 hours. After cooling to room temperature the mixture was fractionated directly on silica gel with chloroform/ethanol gradient) to give 1.5 g of the title compound, suitable for use in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620974 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-25680b9d2119456ca39879f14ba8ca68 |
| Source note | uspto-grants-1997_04 |