(4-Chlorophenyl)acetic acid → HCID 70975934, compound

HRID 535528Notes

Reaction equation

HRID 535528 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][S:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:13][CH2:14][S:15][CH2:16][CH2:17]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:28])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 70976237HCID 70976237, compound

Product 1

HCID 70975934HCID 70975934, compound

Procedure

The product from Example 91B and 2-(4-chlorophenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.49 (s, 1H), 8.29 (d, J=7.8 Hz, 1H), 7.93-8.03 (m, 2H), 7.89 (ddd, J=8.0, 6.2, 1.9 Hz, 1H), 7.34-7.47 (m, 4H), 3.67 (s, 2H), 2.83-2.86 (m, 4H); MS (APCI+) M/Z 415 (M+H)+.

Sources & evidence

ORD record
ord-40ecb26df09e493f855990a44a827235
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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