1-Benzylpiperazine → 4-(4-benzylpiperazin-1-yl)phthalazin-1(2H)-one

HRID 535530Notes

Reaction equation

HRID 535530 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[NH:4][N:3]=1.[CH2:13]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([N:20]1[CH2:25][CH2:24][N:23]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:12])[NH:4][N:3]=2)[CH2:22][CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 27751424-chlorophthalazin-1(2H)-one

Product 1

HCID 709757934-(4-benzylpiperazin-1-yl)phthalazin-1(2H)-one

Procedure

4-Chlorophthalazin-1-one and 1-benzylpiperazine were processed using a method similar to that described in Example 1A to afford the title compound. MS (APCI+) M/Z 321 (M+H)+.

Sources & evidence

ORD record
ord-80bf071f13a2438282008deebda7780b
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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