Methanol → HCID 70976204, compound

Participants

Reaction Steps

To a solution of the product from Example 109C (1.4 g, 3.4 mmol) in THF (8 mL), water (4 mL), and MeOH (8 mL) was added 5M NaOH (3.4 mL, 17 mmol). After stirring at room temperature for 16 hours, the reaction mixture was concentrated to half the volume, diluted to 10 mL (water), washed with DCM, acidified to pH˜2 with aq 3N HCl, and filtered to obtain the precipitated product: 1H NMR (300 MHz, DMSO-d6) δ 12.72 (s, 1H), 11.60 (s, 1H), 8.33 (d, J=7.7, 1H), 8.03-7.97 (m, 2H), 7.91 (ddd, J=8.2, 6.7, 4.0, 1H), 7.41 (s, 4H), 4.40 (q, J=7.1, 1H), 3.69 (s, 2H), 1.45 (d, J=7.1, 3H); MS (ESI+) M/Z 386 (M+H)+.

Provenance & Evidence