(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → Tert-butyl{[4-oxo-3-({[4-(trifluoromethyl)phenyl]acetyl}amino)-3,4-dihydrophthalazin-1-yl]methyl}carbamate

Participants

Reaction Steps

The product of Example 41B and 2-[4-(trifluoromethyl)phenyl]acetic acid were treated using a method similar to that described in Example 56 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.67 (s, 1H), 8.32 (dd, J=7.8, 1.4, 1H), 8.11 (d, J=8.0, 1H), 8.04-7.95 (m, 1H), 7.95-7.86 (m, 1H), 7.76-7.69 (m, 2H), 7.63-7.57 (m, 2H), 7.44-7.37 (m, 1H), 4.48-4.41 (m, 2H), 3.79 (bs, 2H), 1.37 (s, 9H); MS (ESI−) M/Z 475 (M−H)−.

Provenance & Evidence