Neopentylamine → HCID 70976085, compound

HRID 535546Notes

Reaction equation

HRID 535546 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][N:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]([CH2:23][C:24]([OH:26])=O)=[N:13]2)=[O:10])=[CH:4][CH:3]=1.[CH3:27][C:28]([CH3:32])([CH3:31])[CH2:29][NH2:30]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][N:12]2[N:13]=[C:14]([CH2:23][C:24]([NH:30][CH2:29][C:28]([CH3:32])([CH3:31])[CH3:27])=[O:26])[C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:21]2=[O:22])=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 79882NeopentylamineHCID 70976120HCID 70976120, compound

Product 1

HCID 70976085HCID 70976085, compound

Procedure

The product of Example 114 and 2,2-dimethylpropan-1-amine were treated using a method similar to that described in Example 112 to give the title compound. 1H NMR (300 MHz, CDCl3) δ 8.48-8.41 (m, 1H), 8.30 (bs, 1H), 7.97 (d, J=8.0, 1H), 7.92-7.76 (m, 2H), 7.38 (bs, 4H), 6.11-5.98 (m, 1H), 3.89 (s, 2H), 3.80 (bs, 2H), 3.02 (d, J=6.3, 2H), 0.80 (s, 9H); MS (ESI−) M/Z 439 (M−H)−.

Sources & evidence

ORD record
ord-ea7122e155d0409bab690b3a027a04ba
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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