2,2,2-TRIFLUOROETHYL CHLOROFORMATE → HCID 123760671, compound

HRID 535551Notes

Reaction equation

HRID 535551 reaction equation
[NH2:1][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[N:5]([NH:14][C:15](=[O:24])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:4]=1.[C:25](Cl)(=[O:32])[O:26][CH2:27][C:28]([F:31])([F:30])[F:29]>>[F:29][C:28]([F:31])([F:30])[CH2:27][O:26][C:25](=[O:32])[NH:1][CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[N:5]([NH:14][C:15](=[O:24])[CH2:16][C:17]2[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=2)[N:4]=1

Participants

3

Reactant 2

HCID 27696482,2,2-TRIFLUOROETHYL CHLOROFORMATEHCID 70976268HCID 70976268, compound

Product 1

HCID 123760671HCID 123760671, compound

Procedure

The product of Example 42 and 2,2,2-trifluoroethyl carbonochloridate were treated using a method similar to that described in Example 128 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 11.61 (s, 1H), 8.36-8.27 (m, 2H), 8.07 (d, J=7.5, 1H), 8.03-7.96 (m, 1H), 7.95-7.87 (m, 1H), 7.45-7.36 (m, 4H), 4.67 (q, J=9.1, 2H), 4.56 (d, J=5.9, 2H), 3.68 (s, 2H); MS (ESI−) M/Z 467 (M−H)−.

Sources & evidence

ORD record
ord-2ac7817e58264395ac1f362a0fcff2fd
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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