2-[4-(Trifluoromethoxy)phenyl]acetic acid → HCID 70976022, compound

HRID 535554Notes

Reaction equation

HRID 535554 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]([F:33])([F:32])[O:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](O)=[O:30])=[CH:24][CH:23]=1>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:25]3[CH:26]=[CH:27][C:22]([O:21][C:20]([F:32])([F:19])[F:33])=[CH:23][CH:24]=3)[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 27773192-[4-(Trifluoromethoxy)phenyl]acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976022HCID 70976022, compound

Procedure

The product of Example 1B and 2-[4-(trifluoromethoxy)phenyl]acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.50-7.52 (m, 2H), 7.34-7.37 (m, 2H), 3.80-3.84 (m, 4H), 3.75 (s, 2H), 3.07-3.11 (m, 2H); MS (ESI+) M/Z 449 (M+H)+.

Sources & evidence

ORD record
ord-5f5bc4dad3a341eabe0c8a2af471caa8
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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