2-(1,2-Benzoxazol-3-yl)acetic acid → 2-(1,2-benzoxazol-3-yl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(1,2-Benzoxazol-3-yl)acetic acid	HCID 301729	—
Reactant	2-amino-4-morpholinophthalazin-1(2H)-one	HCID 70976104	—
Product	2-(1,2-benzoxazol-3-yl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide	HCID 70976162	—

Reaction Steps

The product of Example 1B and 2-(1,2-benzoxazol-3-yl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.32 (d, J=7.9, 1H), 8.07-7.97 (m, 3H), 7.95-7.89 (m, 1H), 7.76 (d, J=8.4, 1H), 7.69 (ddd, J=8.3, 7.0, 1.1, 1H), 7.48-7.41 (m, 1H), 4.19 (s, 2H), 3.86-3.80 (m, 4H), 3.16-3.07 (m, 4H); MS (ESI+) M/Z 406 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08859549B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-fa5266894e504c4e98392432ce761991
Source note	uspto-grants-2014_10