tert-Butylacetic acid → HCID 70975925, compound

HRID 535556Notes

Reaction equation

HRID 535556 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH3:19][C:20]([CH3:26])([CH3:25])[CH2:21][C:22](O)=[O:23]>>[CH3:19][C:20]([CH3:26])([CH3:25])[CH2:21][C:22]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:23]

Participants

3

Reactant 2

HCID 14057tert-Butylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975925HCID 70975925, compound

Procedure

The product of Example 1B and 3,3-dimethylbutanoic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.2 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.00 (m, 1H), 7.89-7.93 (m, 1H), 3.79-3.84 (m, 4H), 3.08-3.13 (m, 4H), 2.16 (s, 2H), 1.07 (s, 9H); MS (ESI−) M/Z 343 (M−H)−.

Sources & evidence

ORD record
ord-aff9b6b128e4496dab0b50ffb45135e4
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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