Cyclohexaneacetic acid → HCID 70976341, compound

HRID 535559Notes

Reaction equation

HRID 535559 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH:19]1([CH2:25][C:26](O)=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([CH2:25][C:26]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 21363Cyclohexaneacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976341HCID 70976341, compound

Procedure

The product of Example 1B and 2-cyclohexylacetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.8, 1.4 Hz, 1H), 8.03 (dd, J=8.1, 1.3 Hz, 1H), 7.97-8.00 (m, 1H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 3.75-3.83 (m, 4H), 3.08-3.10 (m, 4H), 2.16 (d, J=7.0 Hz, 2H), 1.61-1.83 (m, 6H), 0.96-1.28 (m, 5H); MS (ESI−) M/Z 369 (M−H)−.

Sources & evidence

ORD record
ord-f3a722349c1a4dee9c61944caf9c472b
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

Loading…