HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 53556Generated: October 29, 2026
Acetic Anhydride → 5-acetyl-2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
https://huagongshe.com/reaction/53556
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Dipyridodiazepinone deriv. 15 | HCID 463144 | — |
| Product | 5-acetyl-2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 19960051 | — |
Reaction Steps
A suspension of 2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (5.1 g) in acetic anhydride (25 mL) was heated at 140° C. for 5 hours. The solvent was evaporated and the residue fractionated over silica gel to give 4.48 g of 5-acetyl-2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, suitable for use in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05620974 |
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| Source dataset | uspto-grants-1997_04 |
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| ORD ID | ord-ae17f5cf9c2e45dab4929b25a5be296c |
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| Source note | uspto-grants-1997_04 |
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