o-Tolylacetic acid → HCID 70976113, compound

HRID 535560Notes

Reaction equation

HRID 535560 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27](O)=[O:28]>>[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:28]

Participants

3

Reactant 2

HCID 69519o-Tolylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976113HCID 70976113, compound

Procedure

The product of Example 1B and 2-(2-methylphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.31 (d, J=7.8, 1H), 8.03 (d, J=7.7, 1H), 8.01-7.96 (m, 1H), 7.94-7.87 (m, 1H), 7.33-7.30 (m, 1H), 7.24-7.14 (m, 3H), 3.84-3.81 (m, 4H), 3.68 (s, 2H), 3.15-3.06 (m, 4H), 2.35 (s, 3H); MS (ESI+) M/Z 379 (M+H)+.

Sources & evidence

ORD record
ord-713982f8e73140639a38bf0f08ce349c
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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