3'-Hydroxyphenylacetic acid → HCID 70976158, compound

HRID 535564Notes

Reaction equation

HRID 535564 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[OH:19][C:20]1[CH:21]=[C:22]([CH2:26][C:27](O)=[O:28])[CH:23]=[CH:24][CH:25]=1>>[OH:19][C:20]1[CH:21]=[C:22]([CH2:26][C:27]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:28])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 121223'-Hydroxyphenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976158HCID 70976158, compound

Procedure

The product of Example 1B and 2-(3-hydroxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.31-8.30 (s, 1H), 8.05-8.01 (m, 1H), 8.01-7.96 (m, 1H), 7.93-7.89 (s, 1H), 7.17-7.13 (m, 1H), 6.86-6.77 (m, 2H), 6.68 (dd, J=7.8, 2.0, 1H), 3.87-3.78 (m, 4H), 3.57 (s, 2H), 3.14-3.03 (m, 4H); MS (ESI+) M/Z 381 (M+H)+.

Sources & evidence

ORD record
ord-662fa1e2bccd49a2a2b00b11797b55e7
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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