Benzeneacetic acid, 2-fluoro- → HCID 70975763, compound

HRID 535569Notes

Reaction equation

HRID 535569 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27](O)=[O:28]>>[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:28]

Participants

3

Reactant 2

HCID 67979Benzeneacetic acid, 2-fluoro-HCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975763HCID 70975763, compound

Procedure

The product of Example 1B and 2-(2-fluorophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.46-7.49 (m, 1H), 7.35 (tdd, J=7.7, 5.7, 1.9 Hz, 1H), 7.18-7.23 (m, 2H), 3.81-3.84 (m, 5H), 3.44-3.59 (m, 1H), 3.05-3.14 (m, 4H); MS (ESI+) M/Z 383 (M+H)+.

Sources & evidence

ORD record
ord-727f21896dae44ca9d413e8a35b1a6fe
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

Loading…