2-(4-Fluorophenyl)acetic acid → HCID 70975795, compound

HRID 535571Notes

Reaction equation

HRID 535571 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:28])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 98372-(4-Fluorophenyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975795HCID 70975795, compound

Procedure

The product of Example 1B and 2-(4-fluorophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (dd, J=7.9, 1.3 Hz, 1H), 8.02-8.05 (m, 1H), 7.97-8.01 (m, 1H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 7.40-7.43 (m, 2H), 7.16-7.20 (m, 2H), 3.78-3.83 (m, 4H), 3.70 (s, 2H), 3.04-3.13 (m, 4H); MS (ESI−) M/Z 381 (M−H)−.

Sources & evidence

ORD record
ord-258c949701e844f69ba9998ee45be872
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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