o-Chlorophenylacetic acid → HCID 70976221, compound

HRID 535572Notes

Reaction equation

HRID 535572 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27](O)=[O:28]>>[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:28]

Participants

3

Reactant 2

HCID 17124o-Chlorophenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976221HCID 70976221, compound

Procedure

The product of Example 1B and 2-(2-chlorophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.32 (d, J=8.4 Hz, 1H), 8.02-8.05 (m, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.46-7.54 (m, 2H), 7.31-7.36 (m, 2H), 3.82-3.83 (m, 6H), 3.09-3.12 (m, 4H); MS (ESI−) M/Z 397 (M−H)−.

Sources & evidence

ORD record
ord-e20fa898cbc84a4a9cb31da1fcc2adb4
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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