2-Bromophenylacetic acid → HCID 70975870, compound

HRID 535574Notes

Reaction equation

HRID 535574 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27](O)=[O:28]>>[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][C:27]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:28]

Participants

3

Reactant 2

HCID 877542-Bromophenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975870HCID 70975870, compound

Procedure

The product of Example 1B and 2-(2-bromophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.32 (dd, J=7.9, 1.3 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.90-7.93 (m, 1H), 7.64 (dd, J=7.9, 1.2 Hz, 1H), 7.53 (dd, J=7.6, 1.7 Hz, 1H), 7.39 (td, J=7.5, 1.3 Hz, 1H), 7.23-7.28 (m, 1H), 3.82-3.87 (m, 5H), 3.49-3.62 (m, 1H), 3.09-3.14 (m, 4H); MS (ESI+) M/Z 443 (M+H)+.

Sources & evidence

ORD record
ord-483932c1d60e4fb483ed6ca436a5b25d
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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