3-(Trifluoromethyl)benzeneacetic acid → HCID 70976161, compound

HRID 535581Notes

Reaction equation

HRID 535581 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]([F:32])([F:31])[C:21]1[CH:22]=[C:23]([CH2:27][C:28](O)=[O:29])[CH:24]=[CH:25][CH:26]=1>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:28](=[O:29])[CH2:27][C:23]3[CH:24]=[CH:25][CH:26]=[C:21]([C:20]([F:31])([F:19])[F:32])[CH:22]=3)[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 676953-(Trifluoromethyl)benzeneacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976161HCID 70976161, compound

Procedure

The product of Example 1B and 2-[3-(trifluoromethyl)phenyl]acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 7.97-8.05 (m, 2H), 12.84-3.14 (m, 4H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 7.75-7.76 (bs, 1H), 7.60-7.70 (m, 3H), 3.80-3.86 (m, 6H); MS (ESI+) M/Z 433 (M+H)+.

Sources & evidence

ORD record
ord-ec8473e81a87413ab5be163e24fdb755
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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