HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethoxy)phenylacetic Acid → N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethoxy)phenylacetic Acid | HCID 2777316 | — |
| Reactant | 2-amino-4-morpholinophthalazin-1(2H)-one | HCID 70976104 | — |
| Product | N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide | HCID 70976349 | — |
Reaction Steps
The product of Example 1B and 2-[3-(trifluoromethoxy)phenyl]acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.31 (d, J=7.7, 1H), 8.04 (d, J=7.8, 1H), 8.02-7.96 (m, 1H), 7.94-7.88 (m, 1H), 7.51 (t, J=7.9, 1H), 7.45-7.37 (m, 2H), 7.29 (d, J=8.2, 1H), 3.85-3.79 (m, 4H), 3.76 (s, 2H), 3.14-3.05 (m, 4H); MS (ESI−) M/Z 447 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859549B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-2c5c9041f7134bb48f9fe36003e93db8 |
| Source note | uspto-grants-2014_10 |