2-Naphthaleneacetic acid → HCID 70975890, compound

HRID 535587Notes

Reaction equation

HRID 535587 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][C:20]=1[CH2:29][C:30](O)=[O:31]>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:30](=[O:31])[CH2:29][C:20]3[CH:21]=[CH:22][C:23]4[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:19]=3)[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 113932-Naphthaleneacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975890HCID 70975890, compound

Procedure

The product of Example 1B and 2-(naphthalen-2-yl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.33-8.29 (m, 1H), 8.03-8.01 (m, 1H), 8.01-7.96 (m, 1H), 7.95-7.88 (m, 5H), 7.58-7.49 (m, 3H), 3.85 (s, 2H), 3.84-3.79 (m, 4H), 3.13-3.06 (m, 4H); MS (ESI−) M/Z 413 (M−H)−.

Sources & evidence

ORD record
ord-920a19e5cfcd48abb88febce0de8292c
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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