2,5-Dimethylphenylacetic acid → 2-(2,5-dimethylphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	2,5-Dimethylphenylacetic acid	HCID 83615	—
Reactant	2-amino-4-morpholinophthalazin-1(2H)-one	HCID 70976104	—
Product	2-(2,5-dimethylphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide	HCID 70976168	—

Reaction Steps

The product of Example 1B and 2-(2,5-dimethylphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.02-8.04 (m, 1H), 7.97-8.00 (m, 1H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 7.13 (s, 1H), 7.07 (d, J=7.6 Hz, 1H), 6.99 (d, J=7.7 Hz, 1H), 3.81-3.84 (m, 4H), 3.62 (s, 2H), 3.05-3.11 (m, 4H), 2.29 (s, 3H), 2.26 (s, 3H); MS (ESI+) M/Z 393 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08859549B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-e8e6d24060e749cca418c89cada45dff
Source note	uspto-grants-2014_10