2,3-Dimethoxyphenylacetic acid → 2-(2,3-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

Participants

Reaction Steps

The product of Example 1B and 2-(2,3-dimethoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (d, J=7.9 Hz, 1H), 7.97-8.04 (m, 2H), 7.89-7.92 (m, 1H), 7.04 (t, J=7.8 Hz, 1H), 6.93-6.99 (m, 2H), 3.84-3.81 (d, J=4.2 Hz, 4H), 3.81 (s, 3H), 3.77 (s, 3H), 3.64 (s, 2H), 3.06-3.10 (m, 4H); MS (ESI+) M/Z 425 (M+H)+.

Provenance & Evidence