Benzo-1,3-dioxole-5-acetic acid → HCID 70975886, compound

HRID 535595Notes

Reaction equation

HRID 535595 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[O:19]1[C:23]2[CH:24]=[CH:25][C:26]([CH2:28][C:29](O)=[O:30])=[CH:27][C:22]=2[O:21][CH2:20]1>>[O:19]1[C:23]2[CH:24]=[CH:25][C:26]([CH2:28][C:29]([NH:1][N:2]3[N:11]=[C:10]([N:12]4[CH2:17][CH2:16][O:15][CH2:14][CH2:13]4)[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[C:3]3=[O:18])=[O:30])=[CH:27][C:22]=2[O:21][CH2:20]1

Participants

3

Reactant 2

HCID 76115Benzo-1,3-dioxole-5-acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975886HCID 70975886, compound

Procedure

The product of Example 1B and 2-(1,3-benzodioxol-5-yl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 6.96 (d, J=1.7 Hz, 1H), 6.89 (d, J=7.9 Hz, 1H), 6.84 (dd, J=7.9, 1.7 Hz, 1H), 6.00 (s, 2H), 3.81-3.83 (m, 4H), 3.58 (s, 2H), 3.08-3.10 (m, 4H); MS (ESI+) M/Z 409 (M+H)+.

Sources & evidence

ORD record
ord-3d48d26846714ce4b3f06974af13181c
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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