2,3-Difluorophenylacetic acid → HCID 70976317, compound

HRID 535596Notes

Reaction equation

HRID 535596 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:27][C:28](O)=[O:29]>>[F:19][C:20]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:27][C:28]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:29]

Participants

3

Reactant 2

HCID 5207722,3-Difluorophenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976317HCID 70976317, compound

Procedure

The product of Example 1B and 2-(2,3-difluorophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.91 (td, J=7.5, 1.3 Hz, 1H), 7.35 (dtd, J=10.2, 8.1, 1.9 Hz, 1H), 7.27-7.31 (m, 1H), 7.19-7.25 (m, 1H), 3.81-3.84 (m, 4H), 3.80 (s, 2H), 3.07-3.12 (m, 4H); MS (ESI+) M/Z 401 (M+H)+.

Sources & evidence

ORD record
ord-764d964bdf9a4d4d8ec9c909987e8ca4
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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