2,6-Dichlorophenylacetic acid → HCID 70976298, compound

HRID 535599Notes

Reaction equation

HRID 535599 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=1[CH2:27][C:28](O)=[O:29]>>[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=1[CH2:27][C:28]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:29]

Participants

3

Reactant 2

HCID 810582,6-Dichlorophenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976298HCID 70976298, compound

Procedure

The product of Example 1B and 2-(2,6-dichlorophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (d, J=7.9 Hz, 1H), 8.02-8.08 (m, 1H), 7.96-8.00 (m, 1H), 7.89-7.95 (m, 1H), 7.49-7.51 (m, 2H), 7.30-7.45 (m, 1H), 4.04 (s, 2H), 3.81-3.84 (m, 4H), 3.08-3.12 (m, 4H); MS (ESI+) M/Z 433 (M+H)+.

Sources & evidence

ORD record
ord-35445857af8f490fadd40f0d80c9ef73
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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