4-Chlorophenylacetyl chloride → HCID 70975971, compound

HRID 535607Notes

Reaction equation

HRID 535607 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](Cl)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([S:12][C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70975924HCID 70975924, compound

Product 1

HCID 70975971HCID 70975971, compound

Procedure

The product from Example 191B and (4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 11.84 (s, 1H), 8.44-8.35 (m, 3H), 8.05-7.92 (m, 3H), 7.44-7.35 (m, 4H), 7.29-7.22 (m, 2H), 3.71 (s, 2H); MS (DCI+) M/Z 423 (M+H)+.

Sources & evidence

ORD record
ord-523a69ba9f1b43baaafc786f1a451dbe
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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