4-Chlorophenylacetyl chloride → HCID 70976061, compound

HRID 535615Notes

Reaction equation

HRID 535615 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:17].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](Cl)=[O:27])=[CH:21][CH:20]=1>>[C:13]([S:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:17])[N:2]([NH:1][C:26](=[O:27])[CH2:25][C:22]2[CH:23]=[CH:24][C:19]([Cl:18])=[CH:20][CH:21]=2)[N:11]=1)([CH3:14])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 70976205HCID 70976205, compound

Product 1

HCID 70976061HCID 70976061, compound

Procedure

The product from Example 198B and 2-(4-chlorophenyl)acetyl chloride were processed using a method similar to that described in Example 4C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ 11.74 (s, 1H), 8.32 (d, J=7.9, 1H), 8.12 (d, J=8.0, 1H), 8.01 (t, J=7.6, 1H), 7.93 (t, J=7.5, 1H), 7.44-7.37 (m, 4H), 3.70 (s, 2H), 1.43 (s, 9H); MS (DCI+) M/Z 419 (M+NH4)+.

Sources & evidence

ORD record
ord-75eac35516584d1299a2cb2fb00066e0
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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