(3-Methoxyphenyl)acetic acid → HCID 70976032, compound

HRID 535617Notes

Reaction equation

HRID 535617 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH2:30][C:31](O)=[O:32])[CH:27]=[CH:28][CH:29]=1>>[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH2:30][C:31]([NH:1][N:2]2[N:11]=[C:10]([S:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)(=[O:14])=[O:13])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:21])=[O:32])[CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 15719(3-Methoxyphenyl)acetic acidHCID 70975871HCID 70975871, compound

Product 1

HCID 70976032HCID 70976032, compound

Procedure

The product from Example 68B and 2-(3-methoxyphenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 11.85 (s, 1H), 8.56 (d, J=8.1, 1H), 8.38 (dd, J=8.0, 0.9, 1H), 8.15-8.06 (m, 1H), 8.05-7.96 (m, 3H), 7.84-7.76 (m, 1H), 7.72-7.62 (m, 2H), 7.26 (t, J=7.9, 1H), 6.95-6.88 (m, 1H), 6.85 (dd, J=8.2, 2.6, 2H), 3.77 (s, 3H), 3.64 (s, 2H); MS (ESI+) M/Z 467 (M+NH4)+.

Sources & evidence

ORD record
ord-c3c0432c18c44452ba3327eaa5ec62db
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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