HRID535634

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21193347

1-Phenylpiperidin-4-amine

C11H16N2

结构：O=C([O-])c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1.[Li+]

HCID68787401

未命名化合物

PRODUCTS

生成物

结构：O=C(NC1CCN(c2ccccc2)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1

HCID59636723

未命名化合物

PROCEDURE

实验过程

The compound was prepared according to the procedure disclosed in Example 1 starting from lithium 7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate (70 mg, 0.18 mmol) and 1-phenylpiperidin-4-amine (39 mg, 0.22 mmol). Yield: 34 mg (34%).

WORKUP

后处理

customThe compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0b66843abb7d45dfa73293c6a74e0b17
来源数据集: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08859534B2
来源说明: uspto-grants-2014_10

反应 SMILES

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:23]3[O:22][C:21]([C:24]([O-])=[O:25])=[CH:20][C:19]=3[CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1.[Li+].[C:28]1([N:34]2[CH2:39][CH2:38][CH:37]([NH2:40])[CH2:36][CH2:35]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:28]1([N:34]2[CH2:35][CH2:36][CH:37]([NH:40][C:24]([C:21]3[O:22][C:23]4[C:15]([N:12]5[CH2:13][CH2:14][N:9]([CH2:8][CH2:7][C:2]6[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=6)[CH2:10][CH2:11]5)=[CH:16][CH:17]=[CH:18][C:19]=4[CH:20]=3)=[O:25])[CH2:38][CH2:39]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1