HRID535639

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12760108

1-(3-Chloropyridin-2-yl)piperidin-4-amine

C10H14ClN3

结构：O=C([O-])c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1.[Li+]

HCID68787401

未命名化合物

PRODUCTS

生成物

结构：O=C(NC1CCN(c2ncccc2Cl)CC1)c1cc2cccc(N3CCN(CCc4ccccn4)CC3)c2o1

HCID59636728

未命名化合物

PROCEDURE

实验过程

The compound was prepared according to the procedure disclosed in Example 1 starting from lithium 7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate (80 mg, 0.21 mmol) and 1-(3-chloropyridin-2-yl)piperidin-4-amine (57 mg, 0.27 mmol). Yield: 50 mg (40%).

WORKUP

后处理

customThe compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1cc2030b882046a49b6c8feab0eda577
来源数据集: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08859534B2
来源说明: uspto-grants-2014_10

反应 SMILES

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:23]3[O:22][C:21]([C:24]([O-:26])=O)=[CH:20][C:19]=3[CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1.[Li+].[Cl:28][C:29]1[C:30]([N:35]2[CH2:40][CH2:39][CH:38]([NH2:41])[CH2:37][CH2:36]2)=[N:31][CH:32]=[CH:33][CH:34]=1>>[Cl:28][C:29]1[C:30]([N:35]2[CH2:40][CH2:39][CH:38]([NH:41][C:24]([C:21]3[O:22][C:23]4[C:15]([N:12]5[CH2:11][CH2:10][N:9]([CH2:8][CH2:7][C:2]6[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=6)[CH2:14][CH2:13]5)=[CH:16][CH:17]=[CH:18][C:19]=4[CH:20]=3)=[O:26])[CH2:37][CH2:36]2)=[N:31][CH:32]=[CH:33][CH:34]=1