Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide → 7-(4-(2-(5-Acetamidopyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636743 | — |
| 반응물 | N-(6-vinylpyridin-3-yl)acetamide | HCID 59636765 | — |
| 생성물 | 7-(4-(2-(5-Acetamidopyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide | HCID 59636773 | — |
반응 단계
The compound was prepared according to the procedure disclosed in Example 43 starting from N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.075 g, 0.27 mmol) (Example 39d) and N-(6-vinylpyridin-3-yl)acetamide (0.16 g, 0.96 mmol). The product was purified by preparative HPLC to give the title compound. Yield: 0.055 g (46%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08859534B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-101f1da1c24a4e2e88cc796a61c76ab2 |
| 출처 메모 | uspto-grants-2014_10 |