HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 4-pyridin-3-ylbutanal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-(1,3-Dioxan-2-yl)-3-(3-pyridyl)propane | HCID 19694135 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-pyridin-3-ylbutanal | HCID 11019026 | 94.5% |
Reaction Steps
A solution of 1.5 g (7.8 mmol) of acetal 157 in 10.0 mL of THF and 10.0 mL of 4N HCl was stirred overnight at room temperature and was then neutralized by the slow addition of solid NaHCO3. The reaction mixture was extracted with ethyl acetate, dried over MgSO4 and concentrated to yield 1.1 g of the aldehyde 158. 1H NMR consistent with structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620971 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-953dc2f4bfb341eeba85ea120230ee5d |
| Source note | uspto-grants-1997_04 |