Hydrochloric Acid → HCID 70944882, compound

Participants

Reaction Steps

HCl in 1,4 dioxane (4 mL) at 0° C. was added to a cooled solution of (trans)-2-(4-(benzyloxy)phenyl)-N-(2-(4-methylpiperazin-1-yl)ethyl)cyclopropanamine (120 mg, 1 equiv) in dioxane (5 mL) and stirred for 16 h. The progress of the reaction was monitored by TLC. After completion, it was filtered to obtain 62 mg of (trans)-2-(4-(benzyloxy)phenyl)-N-(2-(4-methylpiperazin-1-yl)ethyl)cyclopropanamine hydrochloride salt. Yield: 43%. 1H-NMR (DMSO-d6) δ (ppm): 1.21 (q, 1H), 1.54 (quin, 1H), 2.76 (s, 3H), 2.91 (br, 2H), 3.09 (br, 2H), 3.28 (br, 2H), 3.44 (br, 2H), 5.08 (s, 2H), 6.94 (d, 2H), 7.11 (d, 2H), 7.33 (m, 1H), 7.40 (m, 4H), 9.50 (br, 1H), 10.92 (br, 1H). MS (M+H): 366.2

Provenance & Evidence