Hydrochloric Acid → HCID 86673374, compound

Participants

Reaction Steps

To a cooled solution of tert-butyl(R)-1-(2-((trans)-2-(6-(benzyloxy)-4′-(trifluoromethyl)biphenyl-3-yl)cyclopropylamino)ethyl)pyrrolidin-3-ylcarbamate (400 mg, 0.67 mmol) in dioxane (8 mL) at 0° C., HCl in 1,4dioxane (4 mL) was added and stirred for 16 h at RT. The progress of the reaction was monitored by TLC. After completion, the solvent was evaporated, residue was triturated with Et2O to get (R)-1-(2-((trans)-2-(6-(benzyloxy)-4′-(trifluoromethyl)biphenyl-3-yl)cyclopropylamino)ethyl)pyrrolidin-3-amine dihydrochloride (380 mg, 95%) as a white solid.

Provenance & Evidence