反应详情

The title compound was synthesized from N-cyclopropyl-6-ethynylpyridazin-3-amine and 2-(4-chloro-3-iodophenyl)-6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole in a manner similar to that described for in Example 1. The title compound was obtained as a khaki solid. Mp: 130-131° C.; 1H NMR (300 MHz, CDCl3) δ: 8.11-8.13 (1H, d, J=6.0 Hz), 7.86 (1H, s), 7.64 (2H, m), 7.42-7.45 (1H, d, J=9.0 Hz), 7.39-7.42 (1H, d, J=9.0 Hz), 7.22 (1H, s), 7.01-7.04 (1H, d, J=9.0 Hz), 6.00 (1H, s), 3.61 (2H, s), 2.60 (1H, m), 2.44 (8H, brs), 2.27 (3H, s), 0.87-0.89 (2H, m), 0.65 (2H, m). HRMS (ESI-TOF+): m/z [M+H]+ calcd for C28H29ClN7: 498.2167. found: 498.2150.