反应详情

The title compound was synthesized from 3-ethynylimidazo[1,2-b]pyridazine and 2-(3-iodo-4-methylphenyl)-6-(4-methyl-1H-imidazol-1-yl)-1H-benzo[d]imidazole (as prepared above) in a manner similar to that described for in Example 1. The title compound was obtained a pale yellow solid. Mp: 182-184° C.; 1H NMR (400 MHz, CD3OD) δ: 8.57 (2H, brs), 8.26 (1H, s), 7.98-8.05 (3H, m), 7.74 (1H, s), 7.68-7.70 (1H, d, J=8.4 Hz), 7.46-7.48 (2H, m), 7.42-7.44 (1H, d, J=8.4 Hz), 7.29-7.33 (1H, dd, J=4.4 and 9.2 Hz), 2.61 (3H, s), 2.31 (3H, s). HRMS (ESI-TOF+): m/z [M+H]+ calcd for C26H20N7: 430.1775. found: 430.1778.