N-cyclopropyl-6-ethynylpyridazin-3-amine → 3-(2-(6-(Cyclopropylamino)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide

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The title compound was synthesized from N-cyclopropyl-6-ethynylpyridazin-3-amine and 3-iodo-4-methyl-N-(4-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide (as prepared above) in a manner similar to that described for in Example 1. The product was obtained as a pale yellow solid. Mp: 125-126° C.; 1H NMR (300 MHz, CDCl3) δ: 9.94 (1H, s), 8.34 (1H, s), 8.20-8.23 (1H, d, J=8.7 Hz), 8.02 (1H, s), 7.86-7.89 (1H, d, J=8.1 Hz), 7.53 (1H, s), 7.39-7.42 (1H, d, J=9.0 Hz), 7.30-7.32 (2H, m), 7.02-7.05 (1H, d, J=9.2 Hz), 6.80 (1H, s), 6.02 (1H, s), 2.58 (1H, m), 2.48 (3H, s), 2.29 (3H, s), 0.87 (2H, m), 0.64 (2H, brs). HRMS (ESI-TOF+): m/z [M+2H]+2 calcd for C28H25F3N6O: 259.1015. found: 259.1023.

Provenance & Evidence