3-Ethynylimidazo[1,2-b]pyridazine → 3-(2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)benzamide

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Reaction Steps

The title compound was synthesized from 3-ethynylimidazo[1,2-b]pyridazine and 3-iodo-4-methyl-N-(4-(4-methyl-1H-imidazol-1-yl)-3(trifluoromethyl)phenyl)benzamide in a manner similar to that described for in Example 1. The title compound was obtained as a light yellow solid. Mp: 124-126° C.; 1H NMR (300 MHz, CDCl3) δ: 9.00 (1H, s), 8.48 (1H, d, J=4.8 Hz), 8.17 (1H, s), 8.09 (3H, m), 7.93-7.95 (1H, d, J=8.7 Hz), 7.86-7.89 (1H, d, J=8.1 Hz), 7.55 (1H, s), 7.39-7.42 (1H, d, J=8.1 Hz), 7.34-7.36 (1H, d, J=8.4 Hz), 7.11-7.16 (1H, dd, J=4.2 and 8.4 Hz), 6.82 (1H, s), 2.64 (3H, s), 2.29 (3H, s). HRMS (ESI-TOF+): m/z [M+H]+ calcd for C27H20F3N6O: 501.1645. found: 501.1626.

Provenance & Evidence