4-(Methylsulfonyl)benzyl Bromide → 5-methyl-2-(4-(methylsulfonyl)benzyl)-3-(methylthio)-7-neopentyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
Reaction equation
CO[C:3]1[CH:28]=[CH:27][C:6]([CH2:7][N:8]2[C:16]([S:17][CH3:18])=[C:15]3[C:10]([N:11]([CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:12](=[O:21])[N:13]([CH3:20])[C:14]3=[O:19])=[N:9]2)=[CH:5][CH:4]=1.BrCC1C=C[C:34]([S:37](C)(=[O:39])=[O:38])=CC=1>>[CH3:20][N:13]1[C:14](=[O:19])[C:15]2=[C:16]([S:17][CH3:18])[N:8]([CH2:7][C:6]3[CH:27]=[CH:28][C:3]([S:37]([CH3:34])(=[O:39])=[O:38])=[CH:4][CH:5]=3)[N:9]=[C:10]2[N:11]([CH2:22][C:23]([CH3:24])([CH3:26])[CH3:25])[C:12]1=[O:21]Participants
3
Reactant 2
Product 1
Procedure
The synthetic procedure of this compound is analogous to EXAMPLE 5 wherein 2-(4-methoxybenzyl)-5-methyl-3-(methylthio)-7-neopentyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione is used instead of 2-(4-methoxybenzyl)-5-methyl-7-neopentyl-3-(phenylthio)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione, and 1-(bromomethyl)-4-(methylsulfonyl)benzene is used instead of 1-(4-(bromomethyl)phenyl)-1H-1,2,4-triazole. MS (ESI) m/z 451.1 [M+H]+.
Sources & evidence
- ORD record
- ord-009b9cabbbcb41d29e5293a2027a4c3a
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08859564B2
Reaction notes
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